![]() 4 Thus, the complicated histological, molecular, and genetic changes of oral and pharynx squamous epithelial tumorigenesis are needed to be thoroughly understood to provide a new therapeutic opportunity and better prognosis for HNSCC patients.Įxperimental animal models, which accurately represent the cellular and molecular changes associated with the initiation and progression of human cancer, are thus of crucial importance in the field of cancer research. 3 Despite the significant advances made in conventional treatment such as surgery, radiotherapy, chemotherapy, or combinations of these over the past decade, HNSCC continues to have a dismal prognosis, with a 5-year overall and disease-free survival of estimated ~50%. Oral squamous cell carcinoma (OSCC) develops from the epithelium of the oral cavity, including tongue, lips, gums, floor of the mouth, cheeks, hard palate, or other unspecified parts of the mouth. 1, 2 HNSCC affects the nasal cavity and paranasal sinuses, the nasopharynx, oropharynx, and the oral cavity. Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy in the world and is the third most common cancer in developing countries. Keywords: head and neck squamous cell carcinoma, HNSCC, mouse models, immunocompromised models, immunocompetent models, transgenic models And thus, this paper will review these two kinds of models applied in head and neck squamous cell carcinoma to provide a platform to understand the complicated histological, molecular, and genetic changes of oral squamous epithelial tumorigenesis. With the development of the recent research on the contribution of immunity/inflammation to cancer initiation and progression, mouse models have been divided into two categories, namely, immunocompromised and immunocompetent mouse models. *These authors contributed equally to this workĪbstract: Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly expand the in vivo research possibilities, and play a critical role in the development of diagnosis, monitoring, and treatment of head and neck squamous cell carcinoma. Zhen-ge Lei, 1,* Xiao-hua Ren, 2,* Sha-sha Wang, 3 Xin-hua Liang, 3,4 Ya-ling Tang 3,5ġDepartment of Oral and Maxillofacial Surgery, Stomatological Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, 2Department of Stomatology, Sichuan Medical Science Academy and Sichuan Provincial People’s Hospital, 3State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, 4Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, 5Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China ![]()
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